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Cover story: Protection against PKD
Zephyr/Science Source
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Lovastatin for cardiolaminopathy
Sayed et al./Science Translation Medicine
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van der Feen 安卓手机看youtube步骤./Science Translational Medicine
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Vol 12, Issue 554
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Pharmacological induction of NRF2 restores redox homeostasis and slows cystogenesis in mouse models of polycystic kidney disease.
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- Clinical trial in a dish using iPSCs shows lovastatin improves endothelial dysfunction and cellular cross-talk in LMNA cardiomyopathy
Patient-specific iPSCs model endothelial dysfunction in lamin A and C–related dilated cardiomyopathy and identify lovastatin as a therapy.
- Editor's Summary
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- Cellular senescence impairs the reversibility of pulmonary arterial hypertension
The transition from reversible to irreversible pulmonary arterial hypertension involves vascular senescence and can be countered by senolysis.
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Infusions of autologous T cells specific for multiple tumor antigens were safe and induced responses in some patients with multiple myeloma.
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- Using influenza surveillance networks to estimate state-specific prevalence of SARS-CoV-2 in the United States
Analysis of influenza-like illness surveillance data estimates that most SARS-CoV-2 infections in the United States went undetected in March 2020.
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- Scientific considerations for global drug development
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- Stimulated bone growth and metal-infused skeletons: From comic books to commonplace
Three-dimensional titanium surfaces patterned with nanometer-sized features demonstrate accelerated bone growth and mineralization in mice.
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- Living swine to maintain donor organs
Use of xenogeneic cross-circulation recovered injured human lungs and expand the pool of donor organs in lung transplantation.
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- Understanding sex-related differences in immune responses
Sex hormone–related changes in neutrophil responsiveness to interferons may underlie differences in immune responses.
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